Product Name :
Remibrutinib
Description:
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment.
CAS:
1787294-07-8
Molecular Weight:
507.53
Formula:
C27H27F2N5O3
Chemical Name:
N-(3-6-amino-5-[2-(N-methylprop-2-enamido)ethoxy]pyrimidin-4-yl-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
Smiles :
CC1C(=CC(F)=CC=1C1=NC=NC(N)=C1OCCN(C)C(=O)C=C)NC(=O)C1=CC=C(C=C1F)C1CC1
InChiKey:
CUABMPOJOBCXJI-UHFFFAOYSA-N
InChi :
InChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.5-Bromo-2-chloro-4-methoxypyrimidine MedChemExpress
Shelf Life:
≥12 months if stored properly.Benzethonium supplier
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33342337
Additional information:
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment.|Product information|CAS Number: 1787294-07-8|Molecular Weight: 507.53|Formula: C27H27F2N5O3|Chemical Name: N-(3-6-amino-5-[2-(N-methylprop-2-enamido)ethoxy]pyrimidin-4-yl-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide|Smiles: CC1C(=CC(F)=CC=1C1=NC=NC(N)=C1OCCN(C)C(=O)C=C)NC(=O)C1=CC=C(C=C1F)C1CC1|InChiKey: CUABMPOJOBCXJI-UHFFFAOYSA-N|InChi: InChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (246.29 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In a biochemical enzyme assay,Remibrutinib (example 6) inhibits Btk enzymatic activity with an IC50 value of 1 nM. In vitro B cell activation assay, Remibrutinib inhibits Btk enzymatic activity in blood with an IC50 value of 0.023 μM, the whole blood is collected from the abdominal aorta of anaesthetized adult male Lewis rats.|Products are for research use only. Not for human use.|
