Product Name :
L-Canavanine sulfate
Description:
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
CAS:
2219-31-0
Molecular Weight:
274.25
Formula:
C5H14N4O7S
Chemical Name:
(2S)-2-amino-4-[(diaminomethylidene)amino]oxybutanoic acid; sulfuric acid
Smiles :
NC(N)=NOCC[C@H](N)C(O)=O.OS(O)(=O)=O
InChiKey:
MVIPJKVMOKFIEV-DFWYDOINSA-N
InChi :
InChI=1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0.(1R,3S)-3-Aminocyclopentane carboxylic acid custom synthesis /s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.|Product information|CAS Number: 2219-31-0|Molecular Weight: 274.25|Formula: C5H14N4O7S|Chemical Name: (2S)-2-amino-4-[(diaminomethylidene)amino]oxybutanoic acid; sulfuric acid|Smiles: NC(N)=NOCC[C@H](N)C(O)=O.OS(O)(=O)=O|InChiKey: MVIPJKVMOKFIEV-DFWYDOINSA-N|InChi: InChI=1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 100 mg/mL (364.63 mM; Need ultrasonic and warming).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Cobicistat Autophagy |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33107782 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro. In arginine-free media, IC50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells.|In Vivo:|Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity.|Products are for research use only. Not for human use.|
