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Product Name :
FTO-IN-1 TFA

Description:
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μM. FTO-IN-1 TFA can be used for the research of cancer.

CAS:

Molecular Weight:
505.27

Formula:
C20H17Cl2F3N4O4

Chemical Name:
2-((2, 6-dichloro-4-(3, 5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-N-hydroxybenzamide 2, 2, 2-trifluoroacetate

Smiles :
CC1NN=C(C)C=1C1=CC(Cl)=C(NC2=CC=CC=C2C(=O)NO)C(Cl)=C1.OC(=O)C(F)(F)F

InChiKey:
QHFDCFXIEHIDKJ-UHFFFAOYSA-N

InChi :
InChI=1S/C18H16Cl2N4O2.C2HF3O2/c1-9-16(10(2)23-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(25)24-26;3-2(4,5)1(6)7/h3-8,21,26H,1-2H3,(H,22,23)(H,24,25);(H,6,7)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of Product information|Molecular Weight: 505.27|Formula: C20H17Cl2F3N4O4|Chemical Name: 2-((2, 6-dichloro-4-(3, 5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-N-hydroxybenzamide 2, 2, 2-trifluoroacetate|Smiles: CC1NN=C(C)C=1C1=CC(Cl)=C(NC2=CC=CC=C2C(=O)NO)C(Cl)=C1.Daclatasvir medchemexpress OC(=O)C(F)(F)F|InChiKey: QHFDCFXIEHIDKJ-UHFFFAOYSA-N|InChi: InChI=1S/C18H16Cl2N4O2.C2HF3O2/c1-9-16(10(2)23-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(25)24-26;3-2(4,5)1(6)7/h3-8,21,26H,1-2H3,(H,22,23)(H,24,25);(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (98.Racotumomab site 96 mM; Need ultrasonic).PMID:32483799 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|FTO-IN-1 TFA (50 μM) inhibits FTO enzyme activity by 62% in vitro. FTO-IN-1 TFA (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively.|Products are for research use only. Not for human use.|

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Author: Potassium channel