Product Name :
AMG 925
Description:
FLX925, also known as AMG-925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD/D835, 28 nM; MV4-11ITD, 16 nM; MV4-11ITD/D835, 19 nM; MV4-11ITD/N841, 16 nM; MV4-11ITD/F691, 73 nM).
CAS:
1401033-86-0
Molecular Weight:
471.55
Formula:
C26H29N7O2
Chemical Name:
2-hydroxy-1-(2-[8-(4-methylcyclohexyl)-4,6,8,11-tetraazatricyclo[7.4.0.0²,⁷]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)ethan-1-one
Smiles :
CC1CCC(CC1)N1C2=NC(NC3=CC=C4CN(CCC4=N3)C(=O)CO)=NC=C2C2=CC=NC=C12
InChiKey:
BBUVDDPUURMFOX-UHFFFAOYSA-N
InChi :
InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Etokimab In stock
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
FLX925, also known as AMG-925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD/D835, 28 nM; MV4-11ITD, 16 nM; MV4-11ITD/D835, 19 nM; MV4-11ITD/N841, 16 nM; MV4-11ITD/F691, 73 nM).|Product information|CAS Number: 1401033-86-0|Molecular Weight: 471.55|Formula: C26H29N7O2|Synonym:|AMG-925|AMG925|Chemical Name: 2-hydroxy-1-(2-[8-(4-methylcyclohexyl)-4,6,8,11-tetraazatricyclo[7.4.0.0²,⁷]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)ethan-1-one|Smiles: CC1CCC(CC1)N1C2=NC(NC3=CC=C4CN(CCC4=N3)C(=O)CO)=NC=C2C2=CC=NC=C12|InChiKey: BBUVDDPUURMFOX-UHFFFAOYSA-N|InChi: InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Guselkumab Epigenetic Reader Domain |Shelf Life: ≥12 months if stored properly.PMID:31642501 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
