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TNF receptor 1 polyclonal antibody
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Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis. Immunohistochemistry analysis of human spleen tissue stained with TNF receptor 1 pAb at 10µg/ml. Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat Immunohistochemistry analysis of human spleen tissue stained with TNF receptor 1 pAb at 10µg/ml.26993-30-6 Purity Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat
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| Alternative Name Tumor necrosis factor receptor 1, TNF-R1 | Application IHC (PS), IP, WB | Application Notes Detects a band of 55kDa by Western blot.82626-01-5 Data Sheet | Formulation Liquid.PMID:30020717 In PBS containing 50% glycerol and 0.09% sodium azide. | GenBank ID X59238 | Host Rabbit | Immunogen Synthetic peptide corresponding to a portion of mouse TNF-R1. The sequence is completely conserved in rat and human. | Recommendation Dilutions/Conditions Immunoprecipitation (12.5µg/ml)Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from rabbit serum. | Species Reactivity Bovine, Dog, Drosophila, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Xenopus, Yeast | UniProt ID P25118 | Unit of Measure (UM) µg
