Product Name :
DCVC
Description:
DCVC (S-[(1E)-1, 2-dichloroethenyl]–L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures.
CAS:
13419-46-0
Molecular Weight:
216.09
Formula:
C5H7Cl2NO2S
Chemical Name:
(2R)-2-amino-3-[(E)-1, 2-dichloroethenyl]sulfanylpropanoic acid
Smiles :
N[C@@H](CS/C(/Cl)=C\Cl)C(O)=O
InChiKey:
PJIHCWJOTSJIPQ-PEQLYWQKSA-N
InChi :
InChI=1S/C5H7Cl2NO2S/c6-1-4(7)11-2-3(8)5(9)10/h1,3H,2,8H2,(H,9,10)/b4-1-/t3-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Triheptanoin Epigenetics
Shelf Life:
≥360 days if stored properly.Gap 26 Immunology/Inflammation
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DCVC (S-[(1E)-1, 2-dichloroethenyl]–L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures.|Product information|CAS Number: 13419-46-0|Molecular Weight: 216.09|Formula: C5H7Cl2NO2S|Chemical Name: (2R)-2-amino-3-[(E)-1, 2-dichloroethenyl]sulfanylpropanoic acid|Smiles: N[C@@H](CS/C(/Cl)=C\Cl)C(O)=O|InChiKey: PJIHCWJOTSJIPQ-PEQLYWQKSA-N|InChi: InChI=1S/C5H7Cl2NO2S/c6-1-4(7)11-2-3(8)5(9)10/h1,3H,2,8H2,(H,9,10)/b4-1-/t3-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 2.5 mg/mL (11.57 mM; Need ultrasonic) H2O : 1.034 mg/mL (4.79 mM; Need ultrasonic and warming)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1, 2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection.PMID:32788398 In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner.|References:|Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6.Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65.Products are for research use only. Not for human use.|
