Product Name :
(S)-Verapamil hydrochloride
Description:
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
CAS:
36622-28-3
Molecular Weight:
491.06
Formula:
C27H39ClN2O4
Chemical Name:
(2S)-2-(3, 4-dimethoxyphenyl)-5-[2-(3, 4-dimethoxyphenyl)ethyl](methyl)amino-2-(propan-2-yl)pentanenitrile hydrochloride
Smiles :
Cl.CC(C)[C@](CCCN(C)CCC1C=CC(OC)=C(C=1)OC)(C#N)C1=CC(OC)=C(C=C1)OC
InChiKey:
DOQPXTMNIUCOSY-YCBFMBTMSA-N
InChi :
InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Methyllycaconitine site
Additional information:
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1.Onvansertib web (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.|Product information|CAS Number: 36622-28-3|Molecular Weight: 491.06|Formula: C27H39ClN2O4|Synonym:|(S)-(-)-Verapamil hydrochloride|Chemical Name: (2S)-2-(3, 4-dimethoxyphenyl)-5-[2-(3, 4-dimethoxyphenyl)ethyl](methyl)amino-2-(propan-2-yl)pentanenitrile hydrochloride|Smiles: Cl.CC(C)[C@](CCCN(C)CCC1C=CC(OC)=C(C=1)OC)(C#N)C1=CC(OC)=C(C=C1)OC|InChiKey: DOQPXTMNIUCOSY-YCBFMBTMSA-N|InChi: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m0.PMID:32925511 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (407.28 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells. (S)-Verapamil hydrochloride is good active form and has the low bioavailability.|References:|Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.Tannergren C, et al. St John’s wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.Products are for research use only. Not for human use.|
