Product Name :
BRCA1-IN-2
Description:
BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.
CAS:
1622262-55-8
Molecular Weight:
544.54
Formula:
C26H33N4O7P
Chemical Name:
[(2S)-2-[3-(1H-indol-3-yl)propanamido]-2-({[(4-phenylbutyl)carbamoyl]methyl}carbamoyl)ethoxy]phosphonic acid
Smiles :
OP(O)(=O)OC[C@H](NC(=O)CCC1=CNC2=CC=CC=C12)C(=O)NCC(=O)NCCCCC1C=CC=CC=1
InChiKey:
TYEYIJQDNULZJQ-QHCPKHFHSA-N
InChi :
InChI=1S/C26H33N4O7P/c31-24(14-13-20-16-28-22-12-5-4-11-21(20)22)30-23(18-37-38(34,35)36)26(33)29-17-25(32)27-15-7-6-10-19-8-2-1-3-9-19/h1-5,8-9,11-12,16,23,28H,6-7,10,13-15,17-18H2,(H,27,32)(H,29,33)(H,30,31)(H2,34,35,36)/t23-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{(-)-Blebbistatin} site|{(-)-Blebbistatin} Inhibitor|{(-)-Blebbistatin} NF-κB|{(-)-Blebbistatin} Technical Information|{(-)-Blebbistatin} Formula|{(-)-Blebbistatin} manufacturer}
Shelf Life:
≥12 months if stored properly.{{Hydroxyurea} site|{Hydroxyurea} Cell Cycle/DNA Damage|{Hydroxyurea} Technical Information|{Hydroxyurea} In Vivo|{Hydroxyurea} supplier|{Hydroxyurea} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.PMID:33207996 31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.|Product information|CAS Number: 1622262-55-8|Molecular Weight: 544.54|Formula: C26H33N4O7P|Chemical Name: [(2S)-2-[3-(1H-indol-3-yl)propanamido]-2-({[(4-phenylbutyl)carbamoyl]methyl}carbamoyl)ethoxy]phosphonic acid|Smiles: OP(O)(=O)OC[C@H](NC(=O)CCC1=CNC2=CC=CC=C12)C(=O)NCC(=O)NCCCCC1C=CC=CC=1|InChiKey: TYEYIJQDNULZJQ-QHCPKHFHSA-N|InChi: InChI=1S/C26H33N4O7P/c31-24(14-13-20-16-28-22-12-5-4-11-21(20)22)30-23(18-37-38(34,35)36)26(33)29-17-25(32)27-15-7-6-10-19-8-2-1-3-9-19/h1-5,8-9,11-12,16,23,28H,6-7,10,13-15,17-18H2,(H,27,32)(H,29,33)(H,30,31)(H2,34,35,36)/t23-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (183.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
