Product Name :
LY487379 hydrochloride
Description:
LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research.
CAS:
353229-59-1
Molecular Weight:
488.91
Formula:
C21H20ClF3N2O4S
Chemical Name:
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-[(pyridin-3-yl)methyl]ethane-1-sulfonamide hydrochloride
Smiles :
Cl.COC1=CC=CC=C1OC1=CC=C(C=C1)N(CC1C=NC=CC=1)S(=O)(=O)CC(F)(F)F
InChiKey:
LPWFRDWTOKLHJC-UHFFFAOYSA-N
InChi :
InChI=1S/C21H19F3N2O4S.{{Decitabine} MedChemExpress|{Decitabine} Cell Cycle/DNA Damage|{Decitabine} Protocol|{Decitabine} Data Sheet|{Decitabine} manufacturer|{Decitabine} Autophagy} ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bemarituzumab} web|{Bemarituzumab} FGFR|{Bemarituzumab} Technical Information|{Bemarituzumab} References|{Bemarituzumab} custom synthesis|{Bemarituzumab} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research.|Product information|CAS Number: 353229-59-1|Molecular Weight: 488.91|Formula: C21H20ClF3N2O4S|Chemical Name: 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-[(pyridin-3-yl)methyl]ethane-1-sulfonamide hydrochloride|Smiles: Cl.PMID:23829314 COC1=CC=CC=C1OC1=CC=C(C=C1)N(CC1C=NC=CC=1)S(=O)(=O)CC(F)(F)F|InChiKey: LPWFRDWTOKLHJC-UHFFFAOYSA-N|InChi: InChI=1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|LY487379 hydrochloride (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage. LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats.|Products are for research use only. Not for human use.|
