Product Name :
TPA 023
Description:
TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM.
CAS:
252977-51-8
Molecular Weight:
395.43
Formula:
C20H22FN7O
Chemical Name:
5-({[7-tert-butyl-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-ethyl-1H-1,2,4-triazole
Smiles :
CCN1N=CN=C1COC1=NN2C(=NN=C2C=C1C(C)(C)C)C1=CC=CC=C1F
InChiKey:
QKIWQBLNTSQOLY-UHFFFAOYSA-N
InChi :
InChI=1S/C20H22FN7O/c1-5-27-17(22-12-23-27)11-29-19-14(20(2,3)4)10-16-24-25-18(28(16)26-19)13-8-6-7-9-15(13)21/h6-10,12H,5,11H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bupivacaine} site|{Bupivacaine} Sodium Channel|{Bupivacaine} Purity & Documentation|{Bupivacaine} In Vivo|{Bupivacaine} manufacturer|{Bupivacaine} Autophagy}
Shelf Life:
≥12 months if stored properly.{{TMX1} web|{TMX1} Apoptosis|{TMX1} Biological Activity|{TMX1} Description|{TMX1} supplier|{TMX1} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23983589
Additional information:
TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM.|Product information|CAS Number: 252977-51-8|Molecular Weight: 395.43|Formula: C20H22FN7O|Chemical Name: 5-({[7-tert-butyl-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-ethyl-1H-1,2,4-triazole|Smiles: CCN1N=CN=C1COC1=NN2C(=NN=C2C=C1C(C)(C)C)C1=CC=CC=C1F|InChiKey: QKIWQBLNTSQOLY-UHFFFAOYSA-N|InChi: InChI=1S/C20H22FN7O/c1-5-27-17(22-12-23-27)11-29-19-14(20(2,3)4)10-16-24-25-18(28(16)26-19)13-8-6-7-9-15(13)21/h6-10,12H,5,11H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|TPA023 displays good receptor occupancy, when administered orally to rats. The dose of TPA023 resulting in 50% occupancy of rat brain GABAA receptors is 0.42 mg/kg, with the corresponding plasma concentration being 25 ng/mL. TPA023 is also efficacious in the mouse pentylenetetrazole-induced seizure model, providing full seizure protection at a dose of 10 mg/kg i.p. (84% occupancy), with the ED50 of 0.19-0.41 nM, for protection against tonic convulsions (1.4 mg/kg i.p.) corresponding to around 50% occupancy. TPA023 (3 mg/kg p.o. in 0.5% methyl cellulose) shows anxiolytic-like effect on rats. TPA023 (0.7, 2.0, and 5 mg/kg, p.o.) blocks ketamine’s cognitive-impairing ability but does not influence the behavioral symptoms of rhesus monkeys.|Products are for research use only. Not for human use.|
