Product Name :
DHBP dibromide
Description:
DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
CAS:
6159-05-3
Molecular Weight:
514.38
Formula:
C24H38Br2N2
Chemical Name:
1,1′-diheptyl-[4,4′-bipyridine]-1,1′-diium dibromide
Smiles :
[Br-].[Br-].CCCCCCC[N+]1C=CC(=CC=1)C1C=C[N+](CCCCCCC)=CC=1
InChiKey:
VRXAJMCFEOESJO-UHFFFAOYSA-L
InChi :
InChI=1S/C24H38N2.2BrH/c1-3-5-7-9-11-17-25-19-13-23(14-20-25)24-15-21-26(22-16-24)18-12-10-8-6-4-2;;/h13-16,19-22H,3-12,17-18H2,1-2H3;2*1H/q+2;;/p-2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.|Product information|CAS Number: 6159-05-3|Molecular Weight: 514.38|Formula: C24H38Br2N2|Chemical Name: 1,1′-diheptyl-[4,4′-bipyridine]-1,1′-diium dibromide|Smiles: [Br-].[Br-].CCCCCCC[N+]1C=CC(=CC=1)C1C=C[N+](CCCCCCC)=CC=1|InChiKey: VRXAJMCFEOESJO-UHFFFAOYSA-L|InChi: InChI=1S/C24H38N2.2BrH/c1-3-5-7-9-11-17-25-19-13-23(14-20-25)24-15-21-26(22-16-24)18-12-10-8-6-4-2;;/h13-16,19-22H,3-12,17-18H2,1-2H3;2*1H/q+2;;/p-2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (58.{{Triptolide} medchemexpress|{Triptolide} Apoptosis|{Triptolide} Biological Activity|{Triptolide} In Vivo|{Triptolide} manufacturer|{Triptolide} Autophagy} 32 mM).{{Metformin} web|{Metformin} PI3K/Akt/mTOR|{Metformin} Technical Information|{Metformin} Formula|{Metformin} supplier|{Metformin} Epigenetic Reader Domain} H2O : 100 mg/mL (194.PMID:23614016 41 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.|Products are for research use only. Not for human use.|
