Product Name :
SUN 1334H
Description:
SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM.
CAS:
607736-84-5
Molecular Weight:
489.38
Formula:
C23H28Cl2F2N2O3
Chemical Name:
(E)-2-((4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)but-2-en-1-yl)oxy)acetic acid dihydrochloride
Smiles :
Cl.Cl.OC(=O)COC/C=C/CN1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
InChiKey:
KAQMKGKFTBFMGE-SEPHDYHBSA-N
InChi :
InChI=1S/C23H26F2N2O3.2ClH/c24-20-7-3-18(4-8-20)23(19-5-9-21(25)10-6-19)27-14-12-26(13-15-27)11-1-2-16-30-17-22(28)29;;/h1-10,23H,11-17H2,(H,28,29);2*1H/b2-1+;;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.{{Sertraline} site|{Sertraline} Neuronal Signaling|{Sertraline} Protocol|{Sertraline} In Vivo|{Sertraline} manufacturer|{Sertraline} Autophagy} 7 nM.{{Protein A/G Agarose} medchemexpress|{Protein A/G Agarose} TGF-beta/Smad|{Protein A/G Agarose} Protocol|{Protein A/G Agarose} Description|{Protein A/G Agarose} supplier} |Product information|CAS Number: 607736-84-5|Molecular Weight: 489.PMID:24633055 38|Formula: C23H28Cl2F2N2O3|Chemical Name: (E)-2-((4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)but-2-en-1-yl)oxy)acetic acid dihydrochloride|Smiles: Cl.Cl.OC(=O)COC/C=C/CN1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1|InChiKey: KAQMKGKFTBFMGE-SEPHDYHBSA-N|InChi: InChI=1S/C23H26F2N2O3.2ClH/c24-20-7-3-18(4-8-20)23(19-5-9-21(25)10-6-19)27-14-12-26(13-15-27)11-1-2-16-30-17-22(28)29;;/h1-10,23H,11-17H2,(H,28,29);2*1H/b2-1+;;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.|In Vivo:|SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects.|Products are for research use only. Not for human use.|
