Product Name :
NSC697923 — Ub-conjugating Enzyme (E2) Inhibitor
Description:
NSC697923 is a cell permeable, potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. It selectively inhibits PMA-induced NF-κB activation, and also inhibits IκBα phosphorylation by both RANKL and LPS. It impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells. It inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, suggesting the Ubc13-Uev1A may be crucial for DLBCL growth. In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. It also shows in vivo antitumor efficacy in NB orthotopic xenografts.
CAS:
343351-67-7
Molecular Weight:
267.26
Formula:
C11H9NO5S
Chemical Name:
2-nitro-5-tosylfuran
Smiles :
CC1C=CC(=CC=1)S(=O)(=O)C1=CC=C(O1)[N+]([O-])=O
InChiKey:
GAUHIPWCDXOLCZ-UHFFFAOYSA-N
InChi :
InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pepinemab} MedChemExpress|{Pepinemab} Purity & Documentation|{Pepinemab} Description|{Pepinemab} manufacturer|{Pepinemab} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NSC697923 is a cell permeable, potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. It selectively inhibits PMA-induced NF-κB activation, and also inhibits IκBα phosphorylation by both RANKL and LPS. It impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells. It inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, suggesting the Ubc13-Uev1A may be crucial for DLBCL growth. In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. It also shows in vivo antitumor efficacy in NB orthotopic xenografts.|Product information|CAS Number: 343351-67-7|Molecular Weight: 267.26|Formula: C11H9NO5S|Chemical Name: 2-nitro-5-tosylfuran|Smiles: CC1C=CC(=CC=1)S(=O)(=O)C1=CC=C(O1)[N+]([O-])=O|InChiKey: GAUHIPWCDXOLCZ-UHFFFAOYSA-N|InChi: InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ofatumumab} site|{Ofatumumab} CD20|{Ofatumumab} Biological Activity|{Ofatumumab} Description|{Ofatumumab} custom synthesis|{Ofatumumab} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:23991096 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|NSC697923 was used at 1-5 µM final concentration in various in vitro assays.|In Vivo:|NSC697923 was administered by IP injection at 10 mg/kg once per day in SH-SY5Y and NGP xenografts.|References:|Pulvino M, et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. (2012) Blood. 120(8):1668-77.Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. (2014) Cell Death Dis. 5:e1079.Products are for research use only. Not for human use.|Documents||
