Product Name :
TIK-301
Description:
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.
CAS:
118702-11-7
Molecular Weight:
280.75
Formula:
C14H17ClN2O2
Chemical Name:
N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide
Smiles :
CC(=O)NC[C@H](C)C1=CNC2=CC(Cl)=C(C=C12)OC
InChiKey:
RKHCTAKUYDTFHE-QMMMGPOBSA-N
InChi :
InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively.{{Nimodipine} site|{Nimodipine} Neuronal Signaling|{Nimodipine} Biological Activity|{Nimodipine} Description|{Nimodipine} supplier|{Nimodipine} Autophagy} TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action.{{Bexarotene} MedChemExpress|{Bexarotene} Vitamin D Related/Nuclear Receptor|{Bexarotene} Purity & Documentation|{Bexarotene} In Vitro|{Bexarotene} manufacturer|{Bexarotene} Autophagy} TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.PMID:25558565 |Product information|CAS Number: 118702-11-7|Molecular Weight: 280.75|Formula: C14H17ClN2O2|Chemical Name: N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide|Smiles: CC(=O)NC[C@H](C)C1=CNC2=CC(Cl)=C(C=C12)OC|InChiKey: RKHCTAKUYDTFHE-QMMMGPOBSA-N|InChi: InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake. The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively.|Products are for research use only. Not for human use.|
