Product Name :
AS1708727
Description:
AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.
CAS:
1253226-93-5
Molecular Weight:
443.37
Formula:
C24H24Cl2N2O2
Chemical Name:
2-cyclopentyl-N-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl]phenyl}-N-methylacetamide
Smiles :
CN(C(=O)CC1CCCC1)C1=CC=C(Cl)C(COC2=CC=CC3=CN=CC=C32)=C1Cl
InChiKey:
OZEZQEPCCWFFJQ-UHFFFAOYSA-N
InChi :
InChI=1S/C24H24Cl2N2O2/c1-28(23(29)13-16-5-2-3-6-16)21-10-9-20(25)19(24(21)26)15-30-22-8-4-7-17-14-27-12-11-18(17)22/h4,7-12,14,16H,2-3,5-6,13,15H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.|Product information|CAS Number: 1253226-93-5|Molecular Weight: 443.{{Clozapine N-oxide} medchemexpress|{Clozapine N-oxide} mAChR|{Clozapine N-oxide} Purity & Documentation|{Clozapine N-oxide} Purity|{Clozapine N-oxide} custom synthesis|{Clozapine N-oxide} Cancer} 37|Formula: C24H24Cl2N2O2|Chemical Name: 2-cyclopentyl-N-{2,4-dichloro-3-[(isoquinolin-5-yloxy)methyl]phenyl}-N-methylacetamide|Smiles: CN(C(=O)CC1CCCC1)C1=CC=C(Cl)C(COC2=CC=CC3=CN=CC=C32)=C1Cl|InChiKey: OZEZQEPCCWFFJQ-UHFFFAOYSA-N|InChi: InChI=1S/C24H24Cl2N2O2/c1-28(23(29)13-16-5-2-3-6-16)21-10-9-20(25)19(24(21)26)15-30-22-8-4-7-17-14-27-12-11-18(17)22/h4,7-12,14,16H,2-3,5-6,13,15H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.{{Posaconazole} web|{Posaconazole} Fungal|{Posaconazole} Purity & Documentation|{Posaconazole} Formula|{Posaconazole} custom synthesis|{Posaconazole} Cancer} 67 mg/mL (93.PMID:24423657 98 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AS1708727 suppresses increases in blood glucose level by inhibiting gluconeogenic gene expression.|In Vivo:|AS1708727 (30 to 300 mg/kg, orally) reduces both blood glucose and triglyceride levels, exhibiting anti-diabetic effects.|Products are for research use only. Not for human use.|
