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Nat. Prod. Bioprospect. (2014) four:11318 DOI 10.1007/s13659-014-0013-ORIGINAL ARTICLETreatment of Iron-Loaded Veterinary Sarcoma by Artemisia annuaElmar Breuer Thomas EfferthReceived: 25 February 2014 / Accepted: 1 April 2014 / Published on the web: 12 April 2014 The Author(s) 2014. This short article is published with open access at SpringerlinkAbstract Artemisinin, a constituent of Artemisia annua L., is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer development in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report around the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as normal treatment was supplemented by adjuvant therapy having a. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without having tumor relapse. Two other dogs struggling with fibrosarcoma and hemangioendothelial sarcoma also showed total remission and are nevertheless alive just after 39 and 26 months, respectively. A. annua was effectively tolerated devoid of noticeable unwanted effects.Olacaftor These 4 situations indicate that A. annua may be a promising herbal drug for cancer therapy. Keywords Artemisinin Asteraceae Scopoletin Veterinary cancer Comparative oncology1 Introduction Artemisia annua L. is usually a medicinal plant used in standard Chinese medicine to treat fever and chills. In the late 1960 and 1970 s, Chinese scientists found that artemisinin, among the list of constituents of A. annua, is active against malaria [1, 2]. The anti-malarial activity of artemisinin was confirmed by several scientists worldwide. Nowadays, derivatives of artemisinin for instance artemether and artesunate are well-established drugs within the fight against malaria. In the 1990 s, the pioneering perform by us and other individuals showed that artemisinin and its derivatives inhibit cancer growth in vitro [3]. In subsequent years, it turned out that artemisinin-type compounds are in a position to kill cell lines of manyE. Breuer Veterinary Clinic for Pets, Mullheim/Baden, Germany T. Efferth ( ) Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany e-mail: [email protected] tumor forms, e.g. leukemia, lymphoma, melanoma, brain tumors, carcinoma on the colon, breast, ovary, lung, kidney, and quite a few other people [80].Sitagliptin phosphate monohydrate Investigations into the mode of action revealed that artemisinin may possibly type active radical oxygen species and carbon-centered radical molecules top to oxidative stress [115], DNA damage [16, 17], adduct formation of distinct target proteins [18, 19], cell cycle arrest [20], interaction with signal transduction pathways [216], induction of apoptosis and autophagy [7, 271], and inhibition of angiogenesis [3235].PMID:24624203 Artemisinin-type drugs have also been shown to act against cancer in vivo working with transplantable murine syngeneic tumors [6, 368] and human xenograft tumors [32, 397]. The clinical efficacy has been described in quite a few reports around the use of these compounds [48, 49] and more recently in c.