Ith statin-induced myopathyLara M. Mangravite1,*, Barbara E. Engelhardt2,12,*, Marisa W. Medina

Ith statin-induced myopathyLara M. Mangravite1,*, Barbara E. Engelhardt2,12,*, Marisa W. Medina3, Joshua D. Smith4, Christopher D. Brown5, Daniel I. Chasman6, Brigham H. Mecham1, Bryan Howie2, Heejung Shim2, Devesh Naidoo3, QiPing Feng7, Mark J. Rieder4,13, Y-D I. Chen8, Jerome I. Rotter8, Paul M. Ridker6, Jemma C. Hopewell9, Sarah Parish9, Jane Armitage9, Rory Collins9, Russell A. Wilke7, Deborah A. Nickerson4, Matthew Stephens2,ten,11, and Ronald M. Krauss3,1SageBionetworks, Seattle, Washington, USA of Human Genetics, University of Chicago, Chicago, Illinois, USA2Department 3Children’sHospital Oakland Research Institute, Oakland, California, USA of Genome Sciences, University of Washington, Seattle, Washington, USA of Genetics, University of Pennsylvania, Philadelphia, PA4Department 5Department 6Centerfor Cardiovascular Illness Prevention, Division of Preventative Medicine, Brigham and Women’s Hospital, Boston, MA7Departmentof Medicine, Division of Clinical Pharmacology, Vanderbilt University Healthcare Center, Nashville, TN, USA Genetics Institute, Cedars-Sinai, Los Angeles, CA8MedicalUsers could view, print, copy, and download text and data-mine the content material in such documents, for the purposes of academic study, topic usually for the complete Circumstances of use:http://www.Axitinib nature/authors/editorial_policies/license.html#terms Correspondence ought to be addressed to: L.M.M. ([email protected]), M.S. ([email protected]), or R.Calcitonin (human) M.PMID:23557924 K. ([email protected]). *These authors contributed equally to this operate. 11These authors co-directed this project. 12Current Address: Biostatistics and Bioinformatics Department and Division of Statistical Science, Duke University, Durham, NC, USA 13Current Address: Adaptive Biotechnologies, Seattle, WA, USA. Author Contributions L.M.M. made experiment and analyses, generated samples, performed analyses, and wrote the manuscript. B.E.E. developed and performed analyses and wrote the manuscript. C.D.B. performed analyses of ENCODE data. B.H.M. created and performed correlation analyses. J.D.S., M.J.R., and D.A.N. generated expression and genotype data. M.W.M. and D.N. created, performed and analyzed functional experiments. B.H. and H.S. developed and performed the imputation methodology, R.A.W, Q.F, J.D.S, M.J.R. and D.A.N collected and genotyped the myopathy cohort from the Marshfield clinic and performed association analyses, J.C.H., S.P, J.A. and R.C. collected and genotyped myopathy cohort from the SEARCH consortium and performed association analyses in that cohort as well as the Heart Protection Study. J.I.R. and Y.I.C. measured creatine kinase in CAP. D.I.C. and P.M.R. measured creatine kinase and performed connected analyses in JUPITER. M.S. supervised, made, and contributed to analyses and participated in manuscript development. R.M.K. supervised the project and participated in experimental design and style and manuscript development. Supplementary Facts is linked to the on line version in the paper at www.nature/nature. The gene expression data has been deposited in the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/) below accession number GSE36868 and in Synapse (synapse.sagebase.org) beneath accession quantity syn299510. Code and analytical output complementary to this analysis are also supply by means of Synapse at: https://www.synapse.org/#!Synapse:syn299510. The genotype information has been deposited within the database for genotypes and phenotypes (dbGaP, http://www.ncbi.nlm.nih.gov/gap).