Ere were small numbers of women with SSc in each age

Ere were small numbers of women with SSc in each age group who were unmarried, as well as small numbers who were married and under age 40. For each age group of married women aged 40 and above, women with SSc were significantly more likely to be sexually impaired than women from the UK population sample. In multivariate logistic get GSK2879552 regression analysis among sexually active women, older women were more likely to be sexually impaired, (OR = 1.05, 95 CI = 1.04?.06, P,0.001), as were those who were married (OR = 1.41, 95 CI = 1.09?.82, P = 0.009). Controlling for age and marital status, women with SSc were significantly more likely to be sexually impaired than women from the general population sample (OR = 1.88, 95 CI = 1.42?.49, P,0.001). The model had adequate discriminative power (cindex = 0.668) and calibration (P = 0.190 for the HL statistic). When education was included in the model, women with more than a high school education level were significantly more likely to be sexually impaired (OR = 1.40, 95 CI = 1.07?.84, P = 0.015). Inclusion of the education variable in the model, however, did not substantively purchase EZH2 inhibitor influence the assocation of any of the other variables in the core model with sexual impairment. Patients with limited SSc were significantly less likely to be sexually active than women from the general population sample (OR = 1.97, 95 CI = 1.41?2.75, P,0.001), controlling for both age and marital status, as were patients with diffuse SSc (OR = 2.15, 95 CI = 1.32?.51, P = 0.002).Comparison of Sexual Domains in SSc and Population SampleDifferences in sexual domain scores between women with SSc and women from the population sample, unadjusted and adjusted for total FSFI score, can be found in Table 4. For all domains of sexual functioning, women with SSc had significantly worse scores, indicating greater impairment, than women from the general population. Controlling for total FSFI scores, pain and lubrication scores were significantly worse for women with SSc. Pain and lubrication scores were more highly correlated amongst women with SSc (r = 0.62, P,0.001) than among women from the population sample (r = 0.36, P,0.001). Correlations of FSFI domain scores with sexual satisfaction scores for the SSc sample and the general population sample can be found in Table 5. For all sexual domains and for the FSFI total score, correlations with sexual satisfaction were substantially higher among women with SSc than among women from the population sample.Sexual Activity in SSc Compared to Population SampleRates of sexual activity, stratified by age group and marital status, are presented in Table 2. There were relatively few women with SSc in the 18?9 and 30?9 age groups for both married and unmarried women. Among all other age group/marital status combinations, women with SSc were significantly less likely to be sexually active than women from the UK population sample. In multivariate logistic regression analysis, older age was significantly associated with a lower likelihood of sexual activity (odds ratio [OR] = 0.94, 95 confidence interval [CI] = 0.93?0.94, P,0.001), while those who were married were more likely to be sexually active (OR = 2.21, 95 CI = 1.82?.68, P,0.001). Controlling for age and marital status, women with SSc were significantly less likely to be sexually 18325633 active than women from the general population sample (OR = 0.34, 95 CI = 0.28?.41, P,0.001). The model had adequate discriminative power (cindex = 0.742) and calibra.Ere were small numbers of women with SSc in each age group who were unmarried, as well as small numbers who were married and under age 40. For each age group of married women aged 40 and above, women with SSc were significantly more likely to be sexually impaired than women from the UK population sample. In multivariate logistic regression analysis among sexually active women, older women were more likely to be sexually impaired, (OR = 1.05, 95 CI = 1.04?.06, P,0.001), as were those who were married (OR = 1.41, 95 CI = 1.09?.82, P = 0.009). Controlling for age and marital status, women with SSc were significantly more likely to be sexually impaired than women from the general population sample (OR = 1.88, 95 CI = 1.42?.49, P,0.001). The model had adequate discriminative power (cindex = 0.668) and calibration (P = 0.190 for the HL statistic). When education was included in the model, women with more than a high school education level were significantly more likely to be sexually impaired (OR = 1.40, 95 CI = 1.07?.84, P = 0.015). Inclusion of the education variable in the model, however, did not substantively influence the assocation of any of the other variables in the core model with sexual impairment. Patients with limited SSc were significantly less likely to be sexually active than women from the general population sample (OR = 1.97, 95 CI = 1.41?2.75, P,0.001), controlling for both age and marital status, as were patients with diffuse SSc (OR = 2.15, 95 CI = 1.32?.51, P = 0.002).Comparison of Sexual Domains in SSc and Population SampleDifferences in sexual domain scores between women with SSc and women from the population sample, unadjusted and adjusted for total FSFI score, can be found in Table 4. For all domains of sexual functioning, women with SSc had significantly worse scores, indicating greater impairment, than women from the general population. Controlling for total FSFI scores, pain and lubrication scores were significantly worse for women with SSc. Pain and lubrication scores were more highly correlated amongst women with SSc (r = 0.62, P,0.001) than among women from the population sample (r = 0.36, P,0.001). Correlations of FSFI domain scores with sexual satisfaction scores for the SSc sample and the general population sample can be found in Table 5. For all sexual domains and for the FSFI total score, correlations with sexual satisfaction were substantially higher among women with SSc than among women from the population sample.Sexual Activity in SSc Compared to Population SampleRates of sexual activity, stratified by age group and marital status, are presented in Table 2. There were relatively few women with SSc in the 18?9 and 30?9 age groups for both married and unmarried women. Among all other age group/marital status combinations, women with SSc were significantly less likely to be sexually active than women from the UK population sample. In multivariate logistic regression analysis, older age was significantly associated with a lower likelihood of sexual activity (odds ratio [OR] = 0.94, 95 confidence interval [CI] = 0.93?0.94, P,0.001), while those who were married were more likely to be sexually active (OR = 2.21, 95 CI = 1.82?.68, P,0.001). Controlling for age and marital status, women with SSc were significantly less likely to be sexually 18325633 active than women from the general population sample (OR = 0.34, 95 CI = 0.28?.41, P,0.001). The model had adequate discriminative power (cindex = 0.742) and calibra.