Product: Ellipticine (hydrochloride)
Patched 1/PTCH Antibody (8A10) Summary
| Immunogen |
PTCH (NP_000255 841 a.a. – 940 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. PKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQAN
|
| Specificity |
PTCH – patched homolog (Drosophila)
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PTCH1
|
| Purity |
IgG purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Patched 1/PTCH Antibody (8A10)
- BCNS
- BCNSFLJ42602
- FLJ26746
- HPE7
- mes
- NBCCS
- patched (Drosophila) homolog
- Patched 1
- patched homolog (Drosophila)
- patched homolog 1 (Drosophila)
- patched homolog 1
- protein patched homolog 1
- PTC
- ptc1
- PTCH protein +12b
- PTCH protein +4
- PTCH protein -10
- PTCH
- PTCH1
- PTCH11
Background
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
