Product: (Z)-Mutagenic Impurity of Tenofovir Disoproxil
PA28 Activator alpha Subunit/PSME1 RNAi Summary
| Specificity |
Homo sapiens proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) (PSME1), transcript variant 1, mRNA
|
| Gene |
PSME1
|
Applications/Dilutions
| Application Notes |
This RNAi causes protein knockdown.
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for PA28 Activator alpha Subunit/PSME1 RNAi
- 11S regulator complex alpha subunit
- 11S Regulator Complex Subunit alpha
- 29-kD MCP activator subunit
- IFI5111
- IFI5111MGC8628
- IGUP I-5111
- Interferon gamma up-regulated I-5111 protein
- interferon-gamma IEF SSP 5111
- interferon-gamma-inducible protein 5111
- PA28 Activator alpha Subunit
- PA28A
- PA28alphaActivator of multicatalytic protease subunit 1
- proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- Proteasome activator 28 subunit alpha
- proteasome activator complex subunit 1
- proteasome activator subunit-1
- PSME1
- REG alpha
- REGalpha
- REG-alpha
Background
Position of the Chimera RNAi. The related RNAi products listed were designed from different accesion number but sharing the same RNAi sequence. Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene. The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo. Chimera RNAi has many advantages over the conventional siRNAs. First, it has been demonstrated to have reliable knock-down for over 10,000 human genes. Because the human genome is composed of an intricate, genetic network, chimera RNAis unique design has successfully obviated the off-target effects including microRNA-based influence. Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected. Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.
