NLRP3/NALP3 Antibody Summary
| Immunogen |
NLRP3 (NP_004886.3, 1 a.a. ~ 1036 a.a) full-length human protein.MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDY
|
| Specificity |
NLRP3 – NLR family, pyrin domain containing 3,
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
NLRP3
|
| Purity |
Protein A purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against transfected lysate for western blot and recombinant protein with GST tag for ELISA and Western Blot. GST tag alone is used as a negative control.
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
Protein A purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for NLRP3/NALP3 Antibody
- AGTAVPRL
- AII
- AII/AVP
- Angiotensin/vasopressin receptor AII/AVP-like
- AVP
- C1orf7
- Caterpiller protein 1.1
- CIAS1
- CLR1.1
- Cold autoinflammatory syndrome 1 protein
- Cold autoinflammatory syndrome 1
- Cryopyrin
- Familial cold autoinflammatory syndrome
- FCAS
- FCU
- Leucine-rich repeat-, and PYD-containing protein 3
- Muckle-Wells syndrome
- MWS
- NACHT
- NACHT, LRR and PYD containing protein 3
- NACHT, LRR and PYD domains-containing protein 3
- NALP3
- NLR family, pyrin domain containing 3
- NLRP3
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3
- PYPAF1
- PYRIN-containing APAF1-like protein 1
Background
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 UTR splice patterns are biologically valid. [provided by RefSeq]
