IKEPP Antibody Summary
| Immunogen |
PDZD3 (NP_079067.2, 1 a.a. ~ 491 a.a) full-length human protein.MEKAADLQDTASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKG
|
| Specificity |
PDZD3 – PDZ domain containing 3,
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PDZD3
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
Protein A purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for IKEPP Antibody
- FLJ22756
- IKEPPPDZK2
- intestinal and kidney enriched PDZ protein
- Intestinal and kidney-enriched PDZ protein
- Na(+)/H(+) exchange regulatory cofactor NHE-RF4
- Na/Pi cotransporter C-terminal-associated protein 2
- naPi-Cap2
- Natrium-phosphate cotransporter IIa C-terminal-associated protein 2
- NHERF4
- NHERF-4
- PDZ domain containing 2
- PDZ domain containing 3
- PDZ domain-containing protein 2
- PDZ domain-containing protein 3
- Sodium-hydrogen exchanger regulatory factor 4
Background
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM]
