HFE Antibody Summary
| Immunogen |
HFE (NP_000401.1, 1 a.a. – 348 a.a.) full-length human protein. MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
|
| Specificity |
Reacts with hemochromatosis.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
HFE
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is reactive against transfected lysate in WB and as a detection antibody in ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
Protein A purified
|
Notes
Quality control test: Antibody reactive against mammalian transfected lysate.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for HFE Antibody
- dJ221C16.10.1
- hemochromatosis
- hereditary hemochromatosis protein HLA-H
- hereditary hemochromatosis protein
- HH
- high Fe
- HLAH
- HLA-HHFE1
- MGC103790
- MHC class I-like protein HFE
- MVCD7
Background
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq]
