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Product: Roflumilast Impurity E

AKAP13 Antibody Summary

Immunogen
AKAP13 (NP_658913.1, 1 a.a. ~ 1058 a.a) full-length human protein.MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHV
Specificity
AKAP13 – A kinase (PRKA) anchor protein 13,
Clonality
Polyclonal
Host
Rabbit
Gene
AKAP13
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA
Application Notes
Antibody reactive against recombinant protein with GST tag on ELISA and western blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for AKAP13 Antibody

  • A kinase (PRKA) anchor protein 13
  • AKAP-LbcAKAP-13
  • A-kinase anchor protein 13
  • A-kinase anchoring protein
  • ARHGEF13
  • Breast cancer nuclear receptor-binding auxiliary protein
  • BRXNon-oncogenic Rho GTPase-specific GTP exchange factor
  • c-lbc
  • FLJ11952
  • FLJ43341
  • Guanine nucleotide exchange factor Lbc
  • HA-3
  • HT31
  • Human thyroid-anchoring protein 31
  • LBCLBC oncogene
  • Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13
  • p47
  • PROTO-LB
  • PROTO-LBC

Background

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins. [provided by RefSeq]

PMID: 23525524

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Author: Potassium channel

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Product: Entacapone

AKAP13 Antibody Summary

Immunogen
AKAP13 (NP_658913.1, 1 a.a. ~ 1058 a.a) full-length human protein.
Clonality
Polyclonal
Host
Mouse
Gene
AKAP13
Purity
Protein G purified
Innovators Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Learn about the Innovators Reward

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
Application Notes
This antibody is useful for Western Blot

Reactivity Notes

This product is reactive against Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for AKAP13 Antibody

  • A kinase (PRKA) anchor protein 13
  • AKAP-LbcAKAP-13
  • A-kinase anchor protein 13
  • A-kinase anchoring protein
  • ARHGEF13
  • Breast cancer nuclear receptor-binding auxiliary protein
  • BRXNon-oncogenic Rho GTPase-specific GTP exchange factor
  • c-lbc
  • FLJ11952
  • FLJ43341
  • Guanine nucleotide exchange factor Lbc
  • HA-3
  • HT31
  • Human thyroid-anchoring protein 31
  • LBCLBC oncogene
  • Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13
  • p47
  • PROTO-LB
  • PROTO-LBC

Background

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 13, also known as Brx (breast cancer nuclear receptor-binding auxiliary protein), Lbc (lymphoid blast crisis oncogene), HA-3 or Ht31 (human thyroid-anchoring protein 31), functions as a cAMP-dependent scaffold anchor for PKA and also has Rho-GEF activity. It is known to regulate TLR2 signaling, NFkappaB activation, protein kinase D activation and participate in Actin stress fiber formation. Seven isoforms exist for AKAP 13 and, depending on the isoform, it localizes to the cytoplasm, nucleus or cell membrane.

PMID: 24362705

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Author: Potassium channel