Product Name :
MK-886
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
494.0
Solubility :
Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Appearance:
White solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Prepare fresh solutions daily.
Description:
FLAP inhibitor Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase.{{366-93-8} MedChemExpress|{366-93-8} Technical Information|{366-93-8} Formula|{366-93-8} custom synthesis} IC50’s for leukotriene biosynthesis: 2.{{2541792-70-3} site|{2541792-70-3} Protocol|{2541792-70-3} In Vivo|{2541792-70-3} manufacturer} 5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
CAS :
118414-82-7
Solubility:
Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Formula:
C27H33ClNO2S·Na
Additional Information :
| Alternative Name L-663,536, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid .PMID:28613730 Na | Appearance White solid. | CAS 118414-82-7 | Couple Target FLAP, PPAR | Couple Type Inhibitor | Formula C27H33ClNO2S·Na | MW 494.0 | Purity ≥98% (HPLC) | Solubility Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). | Unit of Measure (UM) mg
