Product Name :
EPZ005687
Description:
EPZ005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme EZH1. The compound reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild-type cells.
CAS:
1396772-26-1
Molecular Weight:
539.67
Formula:
C32H37N5O3
Chemical Name:
1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-6-{4-[(morpholin-4-yl)methyl]phenyl}-1H-indazole-4-carboxamide
Smiles :
CC1C=C(C)NC(=O)C=1CNC(=O)C1=CC(=CC2=C1C=NN2C1CCCC1)C1=CC=C(CN2CCOCC2)C=C1
InChiKey:
ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
InChi :
InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EPZ005687 is a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme EZH1.{{DPH} web|{DPH} Bcr-Abl|{DPH} Purity & Documentation|{DPH} Description|{DPH} custom synthesis|{DPH} Epigenetics} The compound reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with minimal effects on the proliferation of wild-type cells.{{Ibuprofen} MedChemExpress|{Ibuprofen} Apoptosis|{Ibuprofen} Protocol|{Ibuprofen} Data Sheet|{Ibuprofen} supplier|{Ibuprofen} Epigenetics} |Product information|CAS Number: 1396772-26-1|Molecular Weight: 539.PMID:23357584 67|Formula: C32H37N5O3|Synonym:|EPZ-005687|EPZ 005687|Chemical Name: 1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-6-{4-[(morpholin-4-yl)methyl]phenyl}-1H-indazole-4-carboxamide|Smiles: CC1C=C(C)NC(=O)C=1CNC(=O)C1=CC(=CC2=C1C=NN2C1CCCC1)C1=CC=C(CN2CCOCC2)C=C1|InChiKey: ZOIBZSZLMJDVDQ-UHFFFAOYSA-N|InChi: InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
