Product Name :
Pemetrexed (disodium)
Description:
Pemtrexed disodium is the disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.
CAS:
150399-23-8
Molecular Weight:
471.37
Formula:
C20H19N5Na2O6
Chemical Name:
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid sodium
Smiles :
[Na+].{{Rifampicin} medchemexpress|{Rifampicin} Antibiotic|{Rifampicin} Epigenetics|{Rifampicin} Technical Information|{Rifampicin} References|{Rifampicin} manufacturer} [Na+].NC1NC2NC=C(CCC3C=CC(=CC=3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=2C(=O)N=1
InChiKey:
NYDXNILOWQXUOF-GXKRWWSZSA-L
InChi :
InChI=1S/C20H21N5O6.{{Imidazole} MedChemExpress|{Imidazole} Thrombopoietin Receptor|{Imidazole} Technical Information|{Imidazole} Description|{Imidazole} custom synthesis|{Imidazole} Cancer} 2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;/q;2*+1/p-2/t13-;;/m0../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.PMID:24883330
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pemtrexed disodium is the disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.|Product information|CAS Number: 150399-23-8|Molecular Weight: 471.37|Formula: C20H19N5Na2O6|Synonym:|LY231514 disodium|Alimta disodium|LY 231514 disodium|LY-231514 disodium|Chemical Name: (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid sodium|Smiles: [Na+].[Na+].NC1NC2NC=C(CCC3C=CC(=CC=3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=2C(=O)N=1|InChiKey: NYDXNILOWQXUOF-GXKRWWSZSA-L|InChi: InChI=1S/C20H21N5O6.2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;/q;2*+1/p-2/t13-;;/m0../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
