Product Name :
Mizagliflozin
Description:
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.
CAS:
666843-10-3
Molecular Weight:
564.67
Formula:
C28H44N4O8
Chemical Name:
2,2-dimethyl-3-{[3-(3-methyl-4-{[5-(propan-2-yl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H-pyrazol-4-yl]methyl}phenoxy)propyl]amino}propanamide
Smiles :
CC1=CC(=CC=C1CC1=C(NN=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)C)OCCCNCC(C)(C)C(N)=O
InChiKey:
LREHMKLEOJAVMQ-TXKDOCKMSA-N
InChi :
InChI=1S/C28H44N4O8/c1-15(2)21-19(25(32-31-21)40-26-24(36)23(35)22(34)20(13-33)39-26)12-17-7-8-18(11-16(17)3)38-10-6-9-30-14-28(4,5)27(29)37/h7-8,11,15,20,22-24,26,30,33-36H,6,9-10,12-14H2,1-5H3,(H2,29,37)(H,31,32)/t20-,22-,23+,24-,26+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.{{Hyaluronic acid} MedChemExpress|{Hyaluronic acid} Bacterial|{Hyaluronic acid} Technical Information|{Hyaluronic acid} Formula|{Hyaluronic acid} supplier|{Hyaluronic acid} Epigenetics} |Product information|CAS Number: 666843-10-3|Molecular Weight: 564.{{Patritumab} site|{Patritumab} EGFR|{Patritumab} Technical Information|{Patritumab} References|{Patritumab} custom synthesis|{Patritumab} Autophagy} 67|Formula: C28H44N4O8|Chemical Name: 2,2-dimethyl-3-{[3-(3-methyl-4-{[5-(propan-2-yl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H-pyrazol-4-yl]methyl}phenoxy)propyl]amino}propanamide|Smiles: CC1=CC(=CC=C1CC1=C(NN=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)C)OCCCNCC(C)(C)C(N)=O|InChiKey: LREHMKLEOJAVMQ-TXKDOCKMSA-N|InChi: InChI=1S/C28H44N4O8/c1-15(2)21-19(25(32-31-21)40-26-24(36)23(35)22(34)20(13-33)39-26)12-17-7-8-18(11-16(17)3)38-10-6-9-30-14-28(4,5)27(29)37/h7-8,11,15,20,22-24,26,30,33-36H,6,9-10,12-14H2,1-5H3,(H2,29,37)(H,31,32)/t20-,22-,23+,24-,26+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (177.PMID:23613863 09 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect. Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)|Products are for research use only. Not for human use.|
