Product Name :
Soticlestat
Description:
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. Soticlestat has the potential for epilepsy syndromes research.
CAS:
1429505-03-2
Molecular Weight:
373.45
Formula:
C23H23N3O2
Chemical Name:
4-benzyl-1-{[2,4′-bipyridine]-3-carbonyl}piperidin-4-ol
Smiles :
OC1(CC2C=CC=CC=2)CCN(CC1)C(=O)C1=CC=CN=C1C1C=CN=CC=1
InChiKey:
XKUZMIUSBMCVPP-UHFFFAOYSA-N
InChi :
InChI=1S/C23H23N3O2/c27-22(20-7-4-12-25-21(20)19-8-13-24-14-9-19)26-15-10-23(28,11-16-26)17-18-5-2-1-3-6-18/h1-9,12-14,28H,10-11,15-17H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{CRISPR-Cas9 Protein, S. pyogenes} web|{CRISPR-Cas9 Protein, S. pyogenes} Biological Activity|{CRISPR-Cas9 Protein, S. pyogenes} In stock|{CRISPR-Cas9 Protein, S. pyogenes} manufacturer|{CRISPR-Cas9 Protein, S. pyogenes} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. Soticlestat has the potential for epilepsy syndromes research.|Product information|CAS Number: 1429505-03-2|Molecular Weight: 373.45|Formula: C23H23N3O2|Chemical Name: 4-benzyl-1-{[2,4′-bipyridine]-3-carbonyl}piperidin-4-ol|Smiles: OC1(CC2C=CC=CC=2)CCN(CC1)C(=O)C1=CC=CN=C1C1C=CN=CC=1|InChiKey: XKUZMIUSBMCVPP-UHFFFAOYSA-N|InChi: InChI=1S/C23H23N3O2/c27-22(20-7-4-12-25-21(20)19-8-13-24-14-9-19)26-15-10-23(28,11-16-26)17-18-5-2-1-3-6-18/h1-9,12-14,28H,10-11,15-17H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (267.77 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Carbamazepine} medchemexpress|{Carbamazepine} HDAC|{Carbamazepine} Purity & Documentation|{Carbamazepine} In Vitro|{Carbamazepine} supplier|{Carbamazepine} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:25023702 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM.|In Vivo:|Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus.|Products are for research use only. Not for human use.|
