Product Name :
CEP-33779
Description:
CEP-33779 is a highly selective, orally active, small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors, reduced angiogenesis, and reduced proliferation of tumor cells. Tumor regression correlated with inhibition of STAT3 and NF-κB (RelA/p65) activation in a CEP-33779 dose-dependent manner. The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.
CAS:
1257704-57-6
Molecular Weight:
462.57
Formula:
C24H26N6O2S
Chemical Name:
8-(4-methanesulfonylphenyl)-N-[3-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Smiles :
CN1CCN(CC1)C1=CC(=CC=C1)NC1=NN2C=CC=C(C2=N1)C1C=CC(=CC=1)S(C)(=O)=O
InChiKey:
RFZKSQIFOZZIAQ-UHFFFAOYSA-N
InChi :
InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CEP-33779 is a highly selective, orally active, small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors, reduced angiogenesis, and reduced proliferation of tumor cells. Tumor regression correlated with inhibition of STAT3 and NF-κB (RelA/p65) activation in a CEP-33779 dose-dependent manner. The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.|Product information|CAS Number: 1257704-57-6|Molecular Weight: 462.57|Formula: C24H26N6O2S|Chemical Name: 8-(4-methanesulfonylphenyl)-N-[3-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine|Smiles: CN1CCN(CC1)C1=CC(=CC=C1)NC1=NN2C=CC=C(C2=N1)C1C=CC(=CC=1)S(C)(=O)=O|InChiKey: RFZKSQIFOZZIAQ-UHFFFAOYSA-N|InChi: InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amrubicin} MedChemExpress|{Amrubicin} Anti-infection|{Amrubicin} Protocol|{Amrubicin} References|{Amrubicin} custom synthesis|{Amrubicin} Cancer} |Shelf Life: ≥360 days if stored properly.{{Telotristat} medchemexpress|{Telotristat} Tryptophan Hydroxylase|{Telotristat} Biological Activity|{Telotristat} Data Sheet|{Telotristat} manufacturer|{Telotristat} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23291014 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
