Nalysis. The nearby pharmacist (Laurent Flet) blinded the options. The outcomes were presented (abstract) at

Nalysis. The nearby pharmacist (Laurent Flet) blinded the options. The outcomes were presented (abstract) at the 53th congress from the French Congress of Anaesthesia and Essential Care Medicine (SFAR 2011). Authors’ particulars 1 P e Anesth ie-R nimations, Service d’anesth ie r PPARβ/δ Formulation nimation H el-Dieu, CHU Nantes, Insulin Receptor custom synthesis F-44000 Nantes, France. 2P e Anesth ie-R nimations, Service d’anesth ie r nimation H ital Laennec, CHU Nantes, F-44000 Nantes, France. 3P e Anesth ie-R nimations, Service de r nimation m icale polyvalente, CHU Nantes, F-44000 Nantes, France. 4P e Pharmacie, Service HOTEL-DIEU-Essais cliniques, CHU Nantes, F-44000 Nantes, France. 5Cellule de Biostatistiques-Cellule de promotion la recherche clinique, CHU Nantes, F-44000 Nantes, France. Received: eight December 2012 Revised: 14 December 2012 Accepted: 19 April 2013 Published: 19 April 2013 References 1. Mathers CD, Loncar D: Projections of global mortality and burden of illness from 2002 to 2030. PLoS Med 2006, three:e442. 2. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA: The function of secondary brain injury in determining outcome from extreme head injury. J Trauma 1993, 34:216-222. three. Dutton RP, Stansbury LG, Leone S, Kramer E, Hess JR, Scalea TM: Trauma mortality in mature trauma systems: Are we undertaking superior An evaluation of trauma mortality patterns, 1997-2008. J Trauma 2010, 69:620-626. four. Simma B, Burger R, Falk M, Sacher P, Fanconi S: A prospective, randomized, and controlled study of fluid management in youngsters with severe head injury: lactated Ringer’s resolution versus hypertonic saline. Crit Care Med 1998, 26:1265-1270. 5. Shackford SR, Bourguignon PR, Wald SL, Rogers FB, Osler TM, Clark DE: Hypertonic saline resuscitation of sufferers with head injury: a potential, randomized clinical trial. J Trauma 1998, 44:50-58. six. Bederson JB, Connolly ES Jr, Batjer HH, Dacey RG, Dion JE, Diringer MN, Duldner JE Jr, Harbaugh RE, Patel AB, Rosenwasser RH; American Heart Association: Suggestions for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a particular writing group from the Stroke Council, American Heart Association. Stroke 2009, 40:994-1025. 7. Brain Trauma Foundation American Association of Neurological Surgeons Congress of Neurological Surgeons: Guidelines for the management of extreme traumatic brain injury: 3rd edition. J Neurotrauma 2007, 24(Suppl 1):S1-S106. eight. Yunos NM, Bellomo R, Story D, Kellum J: Bench-to-bedside review: chloride in important illness. Crit Care 2010, 14:226. 9. Yunos NM, Kim IB, Bellomo R, Bailey M, Ho L, Story D, Gutteridge GA, Hart GK: The biochemical effects of restricting chloride-rich fluids in intensive care. Crit Care Med 2011, 39:2419-2424. ten. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M: Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration technique and kidney injury in critically ill adults. JAMA 2012, 308:1566-1572. 11. Roquilly A, Mahe PJ, Demeure Dit Latte D, Loutrel O, Champin P, Di Falco C, Courbe A, Buffenoir K, Hamel O, Lejus C, Sebille V, Asehnoune K: Continuous controlled-infusion of hypertonic saline option in traumatic braininjured sufferers: a 9-year retrospective study. Crit Care 2011, 15:R260. 12. Jentsch TJ, Stein V, Weinreich F, Zdebik AA: Molecular structure and physiological function of chloride channels. Physiol Rev 2002, 82:503-568. 13. Williams EL, Hildebrand KL, McCormick SA, Bedel MJ.