Les in the inclined plane assessment. Serum SOD activities were significantly higher and MDA levels

Les in the inclined plane assessment. Serum SOD activities were significantly higher and MDA levels were significantly lower in the SCI rats of the HBO group than those in the control group, at both 2 and 5 days post-SCI, suggesting an increase in SOD activities and reduced lipid peroxidation caused by oxygen free radicals. This was consistent with the accelerated recovery of neuromotor function in SCI rats withTable 3 Maximum inclined plane angles of sham-SCI, SCI-control and Vesatolimod dose PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/29072704 SCI-HBO ratsGrouping sham-SCI SCI-control SCI-HBO n 15 15 15 Before SCI 63.1 ?1.5 63.4 ?1.3 62.8 ?1.9 5d 63.3 ?1.5 23.1 ?0.9* 33.2 ?1.5*# 10 d 63.0 ?1.4 28.0 ?1.3* 38.9 ?1.9*# 20 d 63.2 ?1.3 31.5 ?1.4* 40.3 ?1.9*#BBB scores of different treatment methods have significant differences, HBO increased the BBB score after SCI and different time after treatment. The difference was significant; different treatment methods and time have interactive effectsMean values ?SD Compared to the before SCI, *P < 0.05; compared to the control group, #P < 0.Sun et al. BMC Neurology (2017) 17:Page 4 ofTable 4 SOD (unit/ml) and MDA (nmol/ml) values of sham-SCI, SCI-control and SCI-HBO ratsGrouping SOD sham-SCI SCI-control SCI-HBO MDA sham-SCI SCI-control SCI-HBO n 15 15 15 15 15 15 Before SCI 65.4 ?1.9 67.8 ?2.1 66.4 ?2.0 3.8 ?0.1 3.7 ?0.2 3.9 ?0.4 2d 65.4 ?2.1 49.2 ?1.7* 66.5 ?1.72# 3.2 ?0.2 4.6 ?0.* #5d 69.4 ?2.0 56.7 ?2.0* 70.9 ?1.9# 3.7 ?0.3 4.5 ?0.1* 3.5 ?0.1#3.4 ?0.Fig. 2 The inclination angle of animals pre- and post SCI surgery. (compared to the sham -SCI, * P < 0.05; compared to the control group, # P < 0.05)Mean values ?SD Compared to the before SCI, *P < 0.05; compared to the control group, #P < 0.HBO treatment. Our results showed that there was a significant difference between the SCI-control and sham-SCI in baseline SOD serum levels indicating that this is likely to be a false positive result. The probable reason of this false result is the limited sample size. Although SOD levels of the SCI-control was higher than the sham-SCI and SCI was able to reduce serum SOD as previous studies, these results were in line with the effect of SCI on SOD. Our previous study has demonstrated that cystic degeneration could be achieved by treatment of SCI [7]. And in this study, cystic degeneration was also observed from our results in the HBO treatment group. This histopathology changing indicated the curative effect of HBO. MDA which is one of the most important products of membrane lipid peroxidation, exacerbates the damage of membrane. Therefore, it is necessary to study the mechanism of lipid peroxidation and the mechanism of lipid peroxidation. MDA plays an important role in mitochondrial respiratory chain complexes. The MDA content is a commonly used indicator in the study of plant senescence physiology and resistance physiology. SOD is a naturally occurring superoxide radical scavenger in the body, which can convert harmful superoxide radicalsinto hydrogen peroxide, and then protect the neuron cells. The combined determination of SOD activity and MDA can indirectly reflect the lipid peroxidation in vivo and the extent of the damage of the cells [2]. Many mechanisms may participate in the accelerated restoration of neuromotor function by HBO treatment of SCI rats: (1) increased supply of oxygen to mitigate hypoxia and edema in the damaged tissue; (2) inhibition of neuronal apoptosis through regulation of apoptosisrelated genes, thus promoting recovery of the reversible neurological.