HGK/MAP4K4 Antibody (3D9) Summary
| Immunogen |
MAP4K4 (NP_663719, 611 a.a. ~ 710 a.a) partial recombinant protein with GST tag.VHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPV
|
| Specificity |
MAP4K4 – mitogen-activated protein kinase kinase kinase kinase 4
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MAP4K4
|
| Purity |
IgG purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against recombinant protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
|
Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for HGK/MAP4K4 Antibody (3D9)
- EC 2.7.11
- EC 2.7.11.1
- FLH21957
- FLJ10410
- hepatocyte progenitor kinase-like/germinal center kinase-like kinase
- HGK
- HGKFLJ20373
- HPK/GCK-like kinase HGK
- KIAA0687
- MAP4K4
- MAPK/ERK kinase kinase kinase 4
- MEK kinase kinase 4
- MEKKK 4
- MEKKK4
- mitogen-activated protein kinase kinase kinase kinase 4
- Nck-interacting kinase
- NIKFLJ90111
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
